SYNVISC (3 Injections) vs. Sodium Hyaluronate
In the treatment of osteoarthritis knee pain, the SYNVISC® (hylan G-F 20) provided superior pain relief compared to Hyalgan® (sodium hyaluronate).1
Because viscosupplements are injected directly into the knee, they have none of the GI or cardiovascular safety issues associated with oral medications. And, SYNVISC was the first viscosupplement that offered up to six months of knee pain relief with only three injections.
Science behind SYNVISC
SYNVISC has a unique composition
Unlike other viscosupplements, SYNVISC is a mixture of two hylan polymers derived from American and Canadian chicken comb hyaluronan. Hylans are produced by chemically cross-linking hyaluronan in two steps.
SYNVISC is hylan G-F 20, meaning it is 80% hylan A fluid plus 20% hylan B gel. This composition yields a molecular weight and viscoelastic properties that closely match healthy synovial fluid.
SYNVISC and Synvisc-One are contraindicated in patients with known hypersensitivity to hyaluronan products or patients with infections in or around the target knee.
SYNVISC treatment has been shown to:
- Increase the elastoviscosity of synovial fluid
- Reduce OA knee pain
SYNVISC vs. sodium hyaluronate
SYNVISC is made from cross-linked sodium hyaluronate2,3
Most viscosupplements have single hyaluronan
All viscosupplements contain hyaluronan (HA), or sodium hyaluronate, a natural complex sugar of the glycosaminoglycan family. HA is a long-chain polymer containing repeating disaccharide units of Na-glucuronate-N-acetylglucosamine. The HA is sourced from either chicken combs or bacterial fermentation. Research has shown that the elastic and viscous properties of articular synovial fluid are mainly due to its HA component. Most approved viscosupplements contain single HA chains.
* Precise placement of the injection into the joint space must be achieved in order to optimize efficacy and minimize adverse reactions. The knee joint should be aspirated before the SYNVISC injection.
Find out more about SYNVISC safety in our Clinical Summary.
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