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SYNVISC® Clinical Efficacy


Long Lasting OA Knee Pain Relief

SYNVISC® provides long-lasting relief for up to 6 months for chronic OA knee pain1

The SYNVISC family delivers maximum duration of relief for chronic OA knee pain among currently approved viscosupplements.1, 3-14, 17

The SYNVISC family has consistently shown significant OA knee pain reduction for up to 6 months compared with baseline in multiple, randomized, controlled studies.1,15-18,a-d

AEs observed with the SYNVISC family of viscosupplements were similar to those for placebo.1,17,18,a,b

At 12 months, patients experienced an average 44.8% reduction in pain from baseline with SYNVISC in a randomized, controlled, clinical trial vs Hyalgan.16,d

  • Secondary outcome observed in study where primary outcome variable was intergroup difference in OA knee pain as measured by VAS at 6 months

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SYNVISC® demonstrated rapid OA knee pain relief as early as week 1 and up to 26 weeks with significant improvement from baseline1,17,a

In the pivotal clinical trial, significant pain reduction from baseline occurred 1 week after the first injection of SYNVISC and lasted through 26 weeks, as assessed by blinded evaluators.1,17,a

WEIGHT-BEARING PAIN: PATIENT ASSESSMENT17, b

 
Walking osteoarthritis knee pain response rates graph

See SYNVISC/Synvisc-One study details ›

Safety

  • AEs related to SYNVISC were reported for 2.2% of injections and 7.2% of patients after a single course of treatment17
  • Most commonly reported device-related AEs with SYNVISC: pain in injected knee, swelling in injected knee, and joint effusion17
  • No severe AEs were observed in the SYNVISC group

Synvisc-One® (hylan G-F 20) is the only single-injection viscosupplement to show superiority vs saline in reducing pain at 6 months in a randomized clinical study2,4-5,18,19

Synvisc-One demonstrated significantly greater improvement in OA knee pain than saline control in the pivotal clinical trial.2,18,b,c

PAIN RELIEF (WOMAC A)

 
Walking osteoarthritis knee pain response rates graph

See SYNVISC/Synvisc-One study details ›

References

  1. Wobig M, Dickhut A, Maier R, Vetter G. Viscosupplementation with hylan G-F 20: a 26-week controlled trial of efficacy and safety in the osteoarthritic knee. Clin Ther. 1998;20(3):410-423.
  2. Chevalier X, Jerosch J, Goupille P, et al. Single, intra-articular treatment with 6 ml hylan G-F 20 in patients with symptomatic primary osteoarthritis of the knee: a randomised, multicentre, double-blind, placebo controlled trial. Ann Rheum Dis. 2010;69(1):113-119.
  3. Gel-One [prescribing information]. Warsaw, IN: Zimmer USA; 2011.
  4. Monovisc summary of safety and effectiveness data. Silver Spring, MD: US Food and Drug Administration; 2014.
  5. Durolane [instructions for use]. Durham, NC: Bioventus LLC; 2017.
  6. Euflexxa [prescribing information]. Parsippany, NJ: Ferring Pharmaceuticals; 2016.
  7. Orthovisc [prescribing information]. Raynham, MA: DePuy Mitek Inc; 2005.
  8. Hyalgan [prescribing information]. Parsippany, NJ: Fidia Pharma USA Inc; 2014.
  9. Supartz FX [prescribing information]. Durham, NC: Bioventus LLC; 2015.
  10. Hymovis [prescribing information]. Parsippany, NJ: Fidia Pharma USA Inc; 2015.
  11. GenVisc 850 [prescribing information]. Doylestown, PA: OrthogenRx Inc; 2015.
  12. Gelsyn-3 [prescribing information]. Pambio-Noranco, Switzerland: Institut Biochimique SA; 2016.
  13. Visco-3 [prescribing information]. Durham, NC: Bioventus LLC; 2016.
  14. TriVisc [prescribing information]. Doylestown, PA: OrthogenRx Inc; 2017.
  15. Caborn D, Rush J, Lanzer W, Parenti D, Murray C. A randomized, single-blind comparison of the efficacy and tolerability of hylan G-F 20 and triamcinolone hexacetonide in patients with osteoarthritis of the knee. J Rheumatol. 2004;31(2):333-343.
  16. Raman R, Dutta A, Day N, Sharma HK, Shaw CJ, Johnson GV. Efficacy of hylan G-F 20 and sodium hyaluronate in the treatment of osteoarthritis of the knee—a prospective randomized clinical trial. Knee. 2008;15(4):318-324.
  17. SYNVISC [prescribing information]. Cambridge, MA: Genzyme Corporation; 2014.
  18. Synvisc-One [prescribing information]. Cambridge, MA: Genzyme Corporation; 2014.
  19. Gel-One summary of safety and effectiveness data. Silver Spring, MD: US Food and Drug Administration; 2016.

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